EFCAB13

Across TCGA patient cohorts, EFCAB13 mutation is significantly associated with the RNA expression of many other genes, with 4,435 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EFCAB13-associated genes across cancer lineages are DCK, SUPV3L1, and SASS6. Each is linked with EFCAB13 in more than 2 cancer types. Because this analysis shows association rather than direction, both EFCAB13-to-partner and partner-to-EFCAB13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCK grouped by EFCAB13-low versus EFCAB13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EFCAB13→partner) and Y-score (partner→EFCAB13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DCK →	+0.659	+2.263	<.001	<.001	3	3
UCEC	SUPV3L1 →	+0.329	+2.010	.001	<.001	3	3
UCEC	SASS6 →	+0.425	+2.086	.004	<.001	3	3
UCEC	ABHD3 →	+0.556	+1.765	<.001	<.001	3	3
UCEC	DFFA →	+0.425	+2.402	<.001	<.001	3	3
UCEC	LZIC →	+0.524	+2.010	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,435 associations by consensus.

DCK by EFCAB13 expression — UCEC

Explore this box plot interactively →