EEFSEC

Across TCGA pan-cancer cohorts, EEFSEC mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated EEFSEC data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher EEFSEC mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated EEFSEC expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, CCRCC, and COAD are the cancer types where EEFSEC mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	II,III,IV	0.424	0.620	.002	17	view →
CCRCC	DFS	Median	All	1.000	0.729	.017	8	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
HNSC	DFS	Median	IV	0.924	1.000	.037	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

EEFSEC–PDAC (OS)

Open the PDAC breakdown →