EEFSEC

Across TCGA pan-cancer cohorts, EEFSEC RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of EEFSEC’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where EEFSEC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EEFSEC is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, HNSC, and LIHC are the cancer types where EEFSEC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EEFSEC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.984	<.001	11	view →
HNSC	Male	IV	+1.077	<.001	8	view →
LIHC	Male	All	+0.670	<.001	8	view →
THCA	All	All	−0.171	.002	7	view →
KICH	Female	All	−0.854	<.001	6	view →
LUSC	Female	All	+0.637	<.001	6	view →
STAD	All	II,III,IV	+0.585	.001	6	view →
KIRP	Male	All	−0.508	<.001	6	view →
BLCA	Female	All	+0.766	.010	5	view →
READ	All	All	+0.533	.006	4	view →
CHOL	All	II,III,IV	+0.809	.032	3	view →
BRCA	All	III,IV	+0.402	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

EEFSEC–COAD

Open the COAD breakdown →