EEFSEC

Across TCGA patient cohorts, EEFSEC mutation is significantly associated with the RNA expression of many other genes, with 1,372 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EEFSEC-associated genes across cancer lineages are MAP6D1, TLR5, and TAF13. Each is linked with EEFSEC in more than 1 cancer types. Because this analysis shows association rather than direction, both EEFSEC-to-partner and partner-to-EEFSEC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAP6D1 grouped by EEFSEC-low versus EEFSEC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EEFSEC→partner) and Y-score (partner→EEFSEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAP6D1 →	+0.552	+2.223	.001	.001	3	2
UCEC	TLR5 →	-0.726	-2.796	<.001	.003	3	2
UCEC	TAF13 →	+0.582	+3.332	.002	.005	3	2
UCEC	IGHG3 →	+2.677	+3.807	<.001	<.001	3	2
UCEC	PSAT1P4 →	+0.150	+1.837	<.001	.003	3	2
UCEC	LAG3 →	+1.294	+2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,372 associations by consensus.

MAP6D1 by EEFSEC expression — UCEC

Explore this box plot interactively →