EEFSEC

Across TCGA patient cohorts, EEFSEC mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EEFSEC-associated genes across cancer lineages are EGFR_pY1068, Shc_pY317, and Caspase-7-cleavedD198. Each is linked with EEFSEC in more than 2 cancer types. Because this analysis shows association rather than direction, both EEFSEC-to-partner and partner-to-EEFSEC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by EEFSEC-low versus EEFSEC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EEFSEC→partner) and Y-score (partner→EEFSEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.267	-2.222	.012	.011	3	2
UCEC	Shc_pY317 →	-0.163	-1.700	.011	.044	3	2
UCEC	Caspase-7-cleavedD198 →	+0.735	+3.189	.003	.010	3	2
UCEC	4E-BP1 →	+0.307	+2.199	.007	.033	2	3
UCEC	A-Raf_pS299 →	-0.118	-2.321	.019	.034	3	1
UCEC	FoxM1 →	+0.228	+2.222	.038	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by EEFSEC expression — UCEC

Explore this box plot interactively →