EEFSEC

Across TCGA cell cohorts, EEFSEC mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EEFSEC-associated genes across cancer lineages are S100G, TFDP3, and SPINK9. Each is linked with EEFSEC in more than 1 cancer types. Because this analysis shows association rather than direction, both EEFSEC-to-partner and partner-to-EEFSEC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S100G grouped by EEFSEC-low versus EEFSEC-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EEFSEC→partner) and Y-score (partner→EEFSEC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	S100G →	+1.651	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	TFDP3 →	+0.018	+4.196	.006	.002	3	1
LARGE_INTESTINE	SPINK9 →	+0.333	+3.793	<.001	.007	3	1
LARGE_INTESTINE	GSC2 →	+0.140	+4.688	<.001	<.001	3	1
BLOOD_Leukemia	GHRHR →	+0.322	+3.705	<.001	.007	3	1
BLOOD_Leukemia	FAM216B →	+0.141	+3.944	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

S100G by EEFSEC expression — LARGE_INTESTINE

Explore this box plot interactively →