EEF2KMT

Across TCGA patient cohorts, EEF2KMT mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EEF2KMT-associated genes across cancer lineages are STAT3_pY705, EGFR_pY1068, and A-Raf_pS299. Each is linked with EEF2KMT in more than 1 cancer types. Because this analysis shows association rather than direction, both EEF2KMT-to-partner and partner-to-EEF2KMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by EEF2KMT-low versus EEF2KMT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EEF2KMT→partner) and Y-score (partner→EEF2KMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.380	-3.459	<.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.415	.010	.003	3	1
UCEC	A-Raf_pS299 →	-0.107	-3.169	.025	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.168	-2.321	.013	.034	3	1
UCEC	JNK2 →	+0.199	+2.179	.013	.034	3	1
UCEC	Ku80 →	+0.214	+1.498	.024	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

STAT3_pY705 by EEF2KMT expression — UCEC

Explore this box plot interactively →