EEF2KMT

Across TCGA cell cohorts, EEF2KMT RNA expression is significantly associated with the go_rna of many other GO terms, with 3,422 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible EEF2KMT-associated GO terms across cancer lineages are Nucleolar large rRNA transcription by RNA polymerase I, rRNA 5'-end processing, and Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with EEF2KMT in more than 16 cancer types. Because this analysis shows association rather than direction, both EEF2KMT-to-partner and partner-to-EEF2KMT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleolar large rRNA transcription by RNA polymerase I grouped by EEF2KMT-low versus EEF2KMT-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EEF2KMT→partner) and Y-score (partner→EEF2KMT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Nucleolar large rRNA transcription by RNA polymerase I →	+0.095	+0.897	<.001	<.001	3	17
BLOOD_Myeloma	rRNA 5'-end processing →	+0.105	+1.272	<.001	<.001	3	15
BLOOD_Myeloma	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.105	+1.272	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	'de novo' UMP biosynthetic process →	+0.113	+0.710	.001	<.001	3	14
LUNG_SCLC	Maturation of 5.8S rRNA →	+0.096	+0.702	.001	<.001	3	14
LARGE_INTESTINE	Endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.109	+0.717	.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,422 associations by consensus.

Nucleolar large rRNA transcription by RNA polymerase I by EEF2KMT expression — BLOOD_Leukemia

Explore this box plot interactively →