EED

Across TCGA patient cohorts, EED mutation is significantly associated with the RNA expression of many other genes, with 3,445 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EED-associated genes across cancer lineages are H3Y1, TUBB1P1, and HMGB3P3. Each is linked with EED in more than 1 cancer types. Because this analysis shows association rather than direction, both EED-to-partner and partner-to-EED results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H3Y1 grouped by EED-low versus EED-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EED→partner) and Y-score (partner→EED) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	H3Y1 →	+0.915	+1.781	<.001	.001	3	2
LUAD	TUBB1P1 →	+0.034	+4.612	<.001	.006	3	2
LUAD	HMGB3P3 →	+0.198	+4.285	.006	.003	3	2
BRCA	MIR668 →	+0.278	+5.586	<.001	.001	3	1
BRCA	RNU1-6P →	+0.240	+4.268	<.001	.008	3	1
UCEC	BCLAF1P2 →	+0.142	+1.946	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,445 associations by consensus.

H3Y1 by EED expression — UCEC

Explore this box plot interactively →