Across TCGA pan-cancer cohorts, EDRF1-DT RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of EDRF1-DT’s most consistent transcriptional readouts.
The strongest signal is observed in kidney chromophobe (KICH), where EDRF1-DT RNA is repressed in tumor relative to normal tissue. In most cancer types EDRF1-DT is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.
KICH, THCA, and KIRC are the cancer types where EDRF1-DT tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EDRF1-DT RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.