EDNRB

Across TCGA patient cohorts, EDNRB mutation is significantly associated with the RNA expression of many other genes, with 6,924 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDNRB-associated genes across cancer lineages are PBK, NUF2, and GINS4. Each is linked with EDNRB in more than 5 cancer types. Because this analysis shows association rather than direction, both EDNRB-to-partner and partner-to-EDNRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBK grouped by EDNRB-low versus EDNRB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDNRB→partner) and Y-score (partner→EDNRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PBK →	+1.129	+3.069	<.001	<.001	3	6
LUSC	NUF2 →	+0.622	+2.724	.007	.003	2	6
UCEC	GINS4 →	+0.856	+2.595	<.001	<.001	3	5
UCEC	ORC6 →	+0.793	+4.269	<.001	<.001	3	5
UCEC	EXO1 →	+0.561	+2.008	.005	.005	3	5
UCEC	ERCC6L →	+0.820	+2.584	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,924 associations by consensus.

PBK by EDNRB expression — UCEC

Explore this box plot interactively →