EDNRB

Across TCGA pan-cancer cohorts, EDNRB RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of EDNRB’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where EDNRB RNA is repressed in tumor relative to normal tissue. In most cancer types EDNRB is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and KICH are the cancer types where EDNRB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EDNRB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−2.313	<.001	12	view →
COAD	All	IV	−1.538	<.001	11	view →
KICH	Female	All	−1.850	<.001	10	view →
LUAD	Female	III,IV	−4.178	<.001	9	view →
LUSC	Female	II,III,IV	−4.894	<.001	8	view →
KIRC	All	All	+0.919	<.001	7	view →
UCEC	All	III,IV	−2.179	<.001	6	view →
BRCA	All	III,IV	−1.940	<.001	6	view →
CHOL	All	All	−1.441	.001	4	view →
LIHC	Female	All	−0.834	<.001	4	view →
HNSC	Male	All	−0.733	.010	4	view →
PRAD	All	All	−0.998	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

EDNRB–BLCA

Open the BLCA breakdown →