EDNRB

Across TCGA patient cohorts, EDNRB mutation is significantly associated with the total protein of many other genes, with 68 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDNRB-associated genes across cancer lineages are ATM, TFRC, and Ku80. Each is linked with EDNRB in more than 2 cancer types. Because this analysis shows association rather than direction, both EDNRB-to-partner and partner-to-EDNRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by EDNRB-low versus EDNRB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDNRB→partner) and Y-score (partner→EDNRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.455	-2.459	.006	.019	3	3
COAD	TFRC →	+0.543	+2.347	.005	.003	3	3
STAD	Ku80 →	+0.263	+1.906	.017	.015	3	2
UCEC	Tuberin →	+0.356	+3.584	<.001	.002	3	2
UCEC	Cyclin-B1 →	+0.540	+3.169	.008	.018	3	2
COAD	EGFR_pY1068 →	-0.379	-3.321	.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 68 associations by consensus.

ATM by EDNRB expression — UCEC

Explore this box plot interactively →