EDNRB

Across TCGA cell cohorts, EDNRB mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible EDNRB-associated genes across cancer lineages are OR4F15, C7orf33, and LGI1. Each is linked with EDNRB in more than 1 cancer types. Because this analysis shows association rather than direction, both EDNRB-to-partner and partner-to-EDNRB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4F15 grouped by EDNRB-low versus EDNRB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDNRB→partner) and Y-score (partner→EDNRB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR4F15 →	+0.006	+5.201	<.001	.006	3	2
LUNG_NSCLC_LUSC	C7orf33 →	+0.435	+4.584	<.001	.001	3	1
BLOOD_Leukemia	LGI1 →	+0.129	+5.539	<.001	.003	3	1
BLOOD_Leukemia	KRT71 →	+0.066	+4.922	<.001	.009	3	1
BLOOD_Leukemia	C1QL2 →	+0.019	+4.922	<.001	.009	3	1
BLOOD_Leukemia	SPPL2C →	+0.012	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

OR4F15 by EDNRB expression — BLOOD_Leukemia

Explore this box plot interactively →