EDNRA

Across TCGA pan-cancer cohorts, EDNRA Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated EDNRA data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher EDNRA Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated EDNRA expression acts as an unfavorable survival marker, although some lineages such as LIHC show a favorable association.

LUAD, BRCA, and HNSC are the cancer types where EDNRA Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.205	0.792	<.001	21	view →
BRCA	OS	Median	II,III,IV	0.103	0.565	.004	12	view →
HNSC	OS	Median	All	0.191	0.751	.003	12	view →
LGG	OS	Median	All	0.350	0.811	.018	6	view →
PRAD	DFS	Median	All	0.096	0.776	<.001	6	view →
LIHC	DFS	Median	II,III,IV	1.000	0.210	.045	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

EDNRA–LUAD (DFS)

Open the LUAD breakdown →