EDNRA

Across TCGA pan-cancer cohorts, EDNRA RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of EDNRA’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EDNRA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EDNRA is over-expressed in tumor, although a few such as BLCA and KIRP show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where EDNRA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EDNRA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.318	<.001	11	view →
KIRC	Female	III,IV	+1.478	<.001	11	view →
COAD	Male	II,III,IV	+1.717	<.001	10	view →
BLCA	Male	All	−2.052	<.001	8	view →
KIRP	Female	All	−1.324	<.001	8	view →
LUSC	All	II,III,IV	−1.207	<.001	7	view →
UCEC	All	All	−2.863	<.001	6	view →
LIHC	Female	II,III,IV	+1.073	<.001	6	view →
BRCA	All	II,III,IV	+0.482	<.001	6	view →
READ	Male	All	+2.476	.010	4	view →
LUAD	Female	All	−0.601	<.001	4	view →
CHOL	All	All	+1.525	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

EDNRA–HNSC

Open the HNSC breakdown →