EDNRA

Across TCGA patient cohorts, EDNRA mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDNRA-associated genes across cancer lineages are p70-S6K_pT389, PCNA, and S6_pS240_S244. Each is linked with EDNRA in more than 1 cancer types. Because this analysis shows association rather than direction, both EDNRA-to-partner and partner-to-EDNRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p70-S6K_pT389 grouped by EDNRA-low versus EDNRA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDNRA→partner) and Y-score (partner→EDNRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p70-S6K_pT389 →	-0.155	-2.999	.034	.035	3	2
UCEC	PCNA →	+0.355	+2.584	<.001	.001	3	2
UCEC	S6_pS240_S244 →	+0.439	+3.183	.004	.009	3	2
UCEC	Shc_pY317 →	-0.164	-2.000	.004	.030	3	2
UCEC	C-Raf →	+0.181	+2.584	<.001	.010	3	2
SKCM	eEF2 →	+0.314	+2.321	.024	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

p70-S6K_pT389 by EDNRA expression — UCEC

Explore this box plot interactively →