EDNRA

Across TCGA cell cohorts, EDNRA RNA expression is significantly associated with the go_rna of many other GO terms, with 1,775 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible EDNRA-associated GO terms across cancer lineages are Regulation of protein localization to cell leading edge, Response to human chorionic gonadotropin, and Renal protein absorption. Each is linked with EDNRA in more than 11 cancer types. Because this analysis shows association rather than direction, both EDNRA-to-partner and partner-to-EDNRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to cell leading edge grouped by EDNRA-low versus EDNRA-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EDNRA→partner) and Y-score (partner→EDNRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of protein localization to cell leading edge →	-0.294	-1.776	<.001	.004	3	12
URINARY_TRACT	Response to human chorionic gonadotropin →	-0.206	-0.793	<.001	.001	3	8
BREAST	Renal protein absorption →	-0.444	-0.909	.001	.001	3	7
URINARY_TRACT	Left ventricular cardiac muscle tissue morphogenesis →	-0.618	-0.765	.004	.005	3	6
OESOPHAGUS	Cardiac neural crest cell migration involved in outflow tract morphogenesis →	-0.238	-0.964	<.001	<.001	2	7
SOFT_TISSUE	Vascular process in circulatory system →	-0.064	-2.201	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,775 associations by consensus.

Regulation of protein localization to cell leading edge by EDNRA expression — LIVER

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