EDN3

Across TCGA pan-cancer cohorts, EDN3 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated EDN3 data layer compared with 29 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher EDN3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated EDN3 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

UCEC and PDAC are the cancer types where EDN3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	All	1.000	0.723	.041	2	view →
PDAC	OS	Median	All	0.867	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

EDN3–UCEC (OS)

Open the UCEC breakdown →