EDN3

Across TCGA pan-cancer cohorts, EDN3 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of EDN3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where EDN3 RNA is repressed in tumor relative to normal tissue. In most cancer types EDN3 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and HNSC are the cancer types where EDN3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EDN3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−3.659	<.001	12	view →
THCA	Male	IV	−6.093	<.001	11	view →
HNSC	Male	II,III,IV	−2.463	<.001	11	view →
KICH	Male	All	−0.992	<.001	11	view →
LUAD	All	III,IV	−1.479	<.001	9	view →
KIRC	All	All	−0.360	<.001	7	view →
BRCA	Female	All	−2.735	<.001	6	view →
KIRP	Male	All	−0.328	.001	6	view →
READ	All	All	−3.557	<.001	5	view →
LUSC	Female	All	−1.272	<.001	5	view →
PRAD	All	All	−1.137	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

EDN3–COAD

Open the COAD breakdown →