EDN3

Across TCGA patient cohorts, EDN3 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,492 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDN3-associated proteins across cancer lineages are HDGFL3, NAXD, and RPS2. Each is linked with EDN3 in more than 4 cancer types. Because this analysis shows association rather than direction, both EDN3-to-partner and partner-to-EDN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EDN3 versus HDGFL3 in LUAD, with a Pearson correlation of 0.30.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (EDN3→partner) and Y-score (partner→EDN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HDGFL3 →	+0.556	+0.426	<.001	.005	3	5
OV	NAXD →	+0.414	+1.390	<.001	.003	3	5
PDAC	RPS2 →	-0.259	-1.270	<.001	<.001	3	4
PDAC	SEPTIN4_S325 →	+0.631	+0.963	<.001	<.001	3	4
BRCA	FGF2 →	+0.829	+0.939	<.001	<.001	3	4
HNSC	LAMA2 →	+1.458	+0.561	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,492 associations by consensus.

EDN3 vs HDGFL3 — LUAD

Explore this scatter interactively →