EDN3

Across TCGA patient cohorts, EDN3 protein abundance is significantly associated with the RNA expression of many other genes, with 870 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EDN3-associated genes across cancer lineages are CCDC18-AS1, ENKD1, and GGT6. Each is linked with EDN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EDN3-to-partner and partner-to-EDN3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EDN3 versus CCDC18-AS1 in UCEC, with a Pearson correlation of 0.50.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDN3→partner) and Y-score (partner→EDN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC18-AS1 →	+0.833	+1.442	.002	.004	3	2
PDAC	ENKD1 →	-0.879	-0.446	.004	.003	3	1
PDAC	GGT6 →	-1.886	-0.359	<.001	.006	3	1
PDAC	FMNL1 →	+0.870	+0.446	.002	.003	3	1
PDAC	GRIN3A →	+0.453	+0.446	.001	.003	3	1
GBM	LINC00370 →	+0.470	+0.735	.005	.009	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 870 associations by consensus.

EDN3 vs CCDC18-AS1 — UCEC

Explore this scatter interactively →