EDN3

Across TCGA cell cohorts, EDN3 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,180 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible EDN3-associated GO terms across cancer lineages are Intracellular pH elevation, Stress granule assembly, and Positive regulation of interleukin-8 production. Each is linked with EDN3 in more than 3 cancer types. Because this analysis shows association rather than direction, both EDN3-to-partner and partner-to-EDN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular pH elevation grouped by EDN3-low versus EDN3-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EDN3→partner) and Y-score (partner→EDN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Intracellular pH elevation →	-0.067	-0.012	.001	.001	3	4
SOFT_TISSUE	Stress granule assembly →	+0.091	+1.837	<.001	.004	3	4
SOFT_TISSUE	Positive regulation of interleukin-8 production →	-0.090	-1.649	<.001	<.001	3	3
SOFT_TISSUE	Regulation of dopamine receptor signaling pathway →	-0.138	-2.061	.001	.008	3	3
LARGE_INTESTINE	Positive regulation of smooth muscle cell migration →	-0.072	-0.249	.001	.001	3	3
SOFT_TISSUE	Lysosomal lumen pH elevation →	-0.295	-1.435	.007	.009	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,180 associations by consensus.

Intracellular pH elevation by EDN3 expression — BLOOD_Lymphoma

Explore this box plot interactively →