EDN3

Across TCGA cell cohorts, EDN3 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible EDN3-associated genes across cancer lineages are MAGEB5, GYPA, and MOG. Each is linked with EDN3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EDN3-to-partner and partner-to-EDN3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by EDN3-low versus EDN3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDN3→partner) and Y-score (partner→EDN3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	GYPA →	+0.089	+3.793	<.001	.007	3	1
LARGE_INTESTINE	MOG →	+0.166	+4.054	<.001	.004	3	1
OVARY	FTMT →	+0.032	+5.196	<.001	.005	3	1
OVARY	KRTAP11-1 →	+0.139	+5.807	<.001	.001	3	1
BLOOD_Leukemia	MYL10 →	+0.022	+4.984	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

MAGEB5 by EDN3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →