EDN1

Across TCGA patient cohorts, EDN1 mutation is significantly associated with the RNA expression of many other genes, with 1,626 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDN1-associated genes across cancer lineages are MIR3648-2, MELK, and MVD. Each is linked with EDN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EDN1-to-partner and partner-to-EDN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3648-2 grouped by EDN1-low versus EDN1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDN1→partner) and Y-score (partner→EDN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR3648-2 →	+0.149	+9.057	<.001	.003	3	2
UCEC	MELK →	+0.906	+3.475	<.001	.002	3	2
UCEC	MVD →	+1.001	+4.032	<.001	<.001	3	2
UCEC	CHAF1A →	+0.866	+3.807	<.001	<.001	3	2
SKCM	CTDP1 →	+0.397	+3.217	.006	.009	3	2
UCEC	MSANTD3 →	+0.588	+2.917	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,626 associations by consensus.

MIR3648-2 by EDN1 expression — BRCA

Explore this box plot interactively →