EDN1

Across TCGA pan-cancer cohorts, EDN1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of EDN1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where EDN1 RNA is repressed in tumor relative to normal tissue. In most cancer types EDN1 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

KICH, KIRC, and LUAD are the cancer types where EDN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EDN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	All	IV	−3.792	<.001	11	view →
KIRC	Male	All	+1.934	<.001	11	view →
LUAD	Male	All	−1.746	<.001	9	view →
LUSC	Female	II,III,IV	−3.788	<.001	8	view →
BRCA	All	III,IV	−1.658	<.001	6	view →
STAD	All	II,III,IV	+1.002	.002	5	view →
KIRP	All	All	−0.844	<.001	5	view →
COAD	All	II,III,IV	−0.659	.004	5	view →
UCEC	All	All	−1.133	.003	4	view →
CHOL	All	All	+1.843	<.001	3	view →
ESCA	Male	All	+1.528	.035	1	view →
THCA	Male	II,III,IV	−0.769	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

EDN1–KICH

Open the KICH breakdown →