EDN1

Across TCGA patient cohorts, EDN1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDN1-associated genes across cancer lineages are 14-3-3_beta, FASN, and FoxM1. Each is linked with EDN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both EDN1-to-partner and partner-to-EDN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by EDN1-low versus EDN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDN1→partner) and Y-score (partner→EDN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.143	-3.301	.002	.010	3	1
UCEC	FASN →	+0.464	+3.000	.011	.036	3	1
UCEC	FoxM1 →	+0.322	+2.584	.007	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.212	-2.571	.006	.011	3	1
UCEC	JNK2 →	+0.218	+2.179	.018	.034	3	1
UCEC	Ku80 →	+0.273	+2.598	.013	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

14-3-3_beta by EDN1 expression — UCEC

Explore this box plot interactively →