EDEM3

Across TCGA patient cohorts, EDEM3 protein abundance is significantly associated with the RNA expression of many other genes, with 11,241 significant associations in total. GBM shows the largest number of these associations.

The most reproducible EDEM3-associated genes across cancer lineages are ARHGAP10, KLHDC1, and PALM. Each is linked with EDEM3 in more than 4 cancer types. Because this analysis shows association rather than direction, both EDEM3-to-partner and partner-to-EDEM3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EDEM3 versus ARHGAP10 in UCEC, with a Pearson correlation of -0.30.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDEM3→partner) and Y-score (partner→EDEM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ARHGAP10 →	-0.637	-0.194	.004	.003	3	5
BRCA	KLHDC1 →	-0.695	-0.227	.001	<.001	3	5
BRCA	PALM →	-1.042	-0.231	.001	<.001	3	5
BRCA	TBC1D9 →	-1.414	-0.201	<.001	<.001	3	4
LSCC	DDB2 →	-0.463	-0.180	.001	<.001	3	4
BRCA	MYO5A →	-0.523	-0.193	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,241 associations by consensus.

EDEM3 vs ARHGAP10 — UCEC

Explore this scatter interactively →