EDEM3

Across TCGA pan-cancer cohorts, EDEM3 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of EDEM3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where EDEM3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EDEM3 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where EDEM3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in EDEM3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.777	<.001	11	view →
THCA	All	II,III,IV	−0.577	<.001	10	view →
LIHC	Male	All	+1.048	<.001	8	view →
BRCA	All	III,IV	+0.880	<.001	6	view →
LUAD	Female	All	+0.622	<.001	6	view →
BLCA	Female	All	+0.590	<.001	6	view →
STAD	Male	All	+0.699	.001	5	view →
KIRC	All	All	+0.311	<.001	5	view →
COAD	Female	All	−0.849	<.001	4	view →
KICH	All	All	−0.780	.002	4	view →
CHOL	All	All	+1.045	.025	2	view →
PRAD	All	All	+0.870	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

EDEM3–HNSC

Open the HNSC breakdown →