EDEM3

Across TCGA patient cohorts, EDEM3 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDEM3-associated genes across cancer lineages are eEF2, A-Raf_pS299, and INPP4B. Each is linked with EDEM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EDEM3-to-partner and partner-to-EDEM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by EDEM3-low versus EDEM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDEM3→partner) and Y-score (partner→EDEM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.303	+2.000	.009	.029	3	2
UCEC	A-Raf_pS299 →	-0.144	-2.000	<.001	<.001	3	2
UCEC	INPP4B →	-0.258	-1.678	.014	.019	3	2
UCEC	JNK_pT183_Y185 →	-0.182	-1.986	<.001	<.001	3	2
UCEC	MEK1 →	+0.434	+2.000	<.001	<.001	3	2
UCEC	Notch1 →	+0.134	+1.594	.003	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

eEF2 by EDEM3 expression — UCEC

Explore this box plot interactively →