EDEM3

Across TCGA cell cohorts, EDEM3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,402 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible EDEM3-associated GO terms across cancer lineages are Protein demannosylation, Protein alpha-1,2-demannosylation, and Endoplasmic reticulum mannose trimming. Each is linked with EDEM3 in more than 14 cancer types. Because this analysis shows association rather than direction, both EDEM3-to-partner and partner-to-EDEM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein demannosylation grouped by EDEM3-low versus EDEM3-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EDEM3→partner) and Y-score (partner→EDEM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Protein demannosylation →	+0.112	+0.827	.009	.008	3	15
OESOPHAGUS	Protein alpha-1,2-demannosylation →	+0.112	+0.827	.009	.008	3	15
URINARY_TRACT	Endoplasmic reticulum mannose trimming →	+0.112	+0.670	<.001	<.001	3	15
URINARY_TRACT	Protein deglycosylation →	+0.097	+0.657	<.001	<.001	3	15
SOFT_TISSUE	Ubiquitin-dependent glycoprotein ERAD pathway →	+0.176	+0.802	<.001	<.001	3	14
LIVER	Mannose trimming involved in glycoprotein ERAD pathway →	+0.176	+0.770	<.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,402 associations by consensus.

Protein demannosylation by EDEM3 expression — OESOPHAGUS

Explore this box plot interactively →