EDEM3

Across TCGA cell cohorts, EDEM3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible EDEM3-associated genes across cancer lineages are IL21, CYLC1, and GRXCR1. Each is linked with EDEM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EDEM3-to-partner and partner-to-EDEM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL21 grouped by EDEM3-low versus EDEM3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDEM3→partner) and Y-score (partner→EDEM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	IL21 →	+0.143	+4.930	<.001	.008	3	1
SOFT_TISSUE	CYLC1 →	+0.036	+4.930	<.001	.008	3	1
SOFT_TISSUE	GRXCR1 →	+0.090	+5.977	<.001	.001	3	1
LUNG_NSCLC_LUAD	OR9G4 →	+0.049	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	KRTAP17-1 →	+0.032	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR10G4 →	+0.016	+5.228	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

IL21 by EDEM3 expression — SOFT_TISSUE

Explore this box plot interactively →