EDEM2

Across TCGA patient cohorts, EDEM2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,162 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible EDEM2-associated genes across cancer lineages are CYTIP, EAF2, and CCNB1IP1. Each is linked with EDEM2 in more than 3 cancer types. Because this analysis shows association rather than direction, both EDEM2-to-partner and partner-to-EDEM2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, EDEM2 versus CYTIP in LSCC, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDEM2→partner) and Y-score (partner→EDEM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	CYTIP →	+0.838	+0.202	<.001	<.001	3	4
HNSC	EAF2 →	+0.908	+0.271	<.001	<.001	3	4
LSCC	CCNB1IP1 →	-0.731	-0.249	<.001	<.001	3	4
LSCC	TTC5 →	-0.360	-0.172	.003	.001	3	4
LSCC	ZNF16 →	-0.613	-0.231	<.001	<.001	3	4
GBM	TIGD1 →	-0.506	-0.311	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,162 associations by consensus.

EDEM2 vs CYTIP — LSCC

Explore this scatter interactively →