EDEM2

Across TCGA patient cohorts, EDEM2 mutation is significantly associated with the RNA expression of many other genes, with 2,872 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDEM2-associated genes across cancer lineages are MIR8061, LINC01946, and RNA5SP65. Each is linked with EDEM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both EDEM2-to-partner and partner-to-EDEM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR8061 grouped by EDEM2-low versus EDEM2-high in SARC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDEM2→partner) and Y-score (partner→EDEM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SARC	MIR8061 →	+0.604	+6.649	<.001	<.001	3	2
LUAD	LINC01946 →	+0.200	+4.345	.008	.007	3	2
CESC	RNA5SP65 →	+0.358	+4.559	<.001	.006	3	2
CESC	CPLX3 →	+0.013	+4.757	<.001	.004	3	2
SARC	GYG2-AS1 →	+0.106	+5.005	<.001	.009	3	2
LUSC	OR5M6P →	+0.295	+3.607	.005	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,872 associations by consensus.

MIR8061 by EDEM2 expression — SARC

Explore this box plot interactively →