Across TCGA pan-cancer cohorts, EDDM3DP RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of EDDM3DP’s most consistent transcriptional readouts.
The strongest signal is observed in lung adenocarcinoma (LUAD), where EDDM3DP RNA is more highly expressed in tumor relative to normal tissue. In most cancer types EDDM3DP is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
LUAD, BRCA, and BLCA are the cancer types where EDDM3DP tumor–normal differential expression is most reproducible.