EDDM3A

Across TCGA patient cohorts, EDDM3A mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDDM3A-associated genes across cancer lineages are ASNS, EGFR_pY1173, and eIF4G. Each is linked with EDDM3A in more than 1 cancer types. Because this analysis shows association rather than direction, both EDDM3A-to-partner and partner-to-EDDM3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by EDDM3A-low versus EDDM3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDDM3A→partner) and Y-score (partner→EDDM3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.535	+2.115	<.001	.019	3	2
UCEC	EGFR_pY1173 →	+0.074	+1.611	.035	.043	3	1
UCEC	eIF4G →	+0.399	+3.169	.003	.018	3	1
UCEC	A-Raf_pS299 →	-0.130	-3.321	.012	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.235	-2.794	.001	.003	3	1
UCEC	Ku80 →	+0.282	+2.128	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ASNS by EDDM3A expression — UCEC

Explore this box plot interactively →