EDDM3A

Across TCGA pan-cancer cohorts, EDDM3A RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated EDDM3A data layer compared with 5 for mutation status.

The strongest signal is observed in stomach adenocarcinoma (STAD), where higher EDDM3A RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated EDDM3A expression acts as an unfavorable survival marker, although some lineages such as KIRP and ESCA show a favorable association.

STAD, LUSC, and KICH are the cancer types where EDDM3A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
STAD	DFS	Median	All	0.574	0.803	<.001	72	view →
LUSC	DFS	Tertile	II,III,IV	0.400	0.658	<.001	48	view →
KICH	OS	Tertile	II,III,IV	0.715	1.000	.005	40	view →
LGG	OS	Tertile	All	0.678	0.853	<.001	38	view →
UCEC	DFS	Quartile	All	0.847	0.915	.007	28	view →
KIRP	OS	Quartile	II,III,IV	0.968	0.643	.006	26	view →
SCLC	DFS	Tertile	III,IV	0.258	0.587	.015	18	view →
MESO	OS	Tertile	III,IV	0.311	0.593	.032	18	view →
CHOL	OS	Tertile	All	0.089	0.673	.018	18	view →
SKCM	DFS	Tertile	III,IV	0.480	0.690	.033	9	view →
KIRC	DFS	Tertile	II,III,IV	0.566	0.706	.037	8	view →
COAD	DFS	Tertile	II,III,IV	0.362	0.563	.049	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

EDDM3A–STAD (DFS)

Open the STAD breakdown →