EDC4

Across TCGA pan-cancer cohorts, EDC4 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated EDC4 data layer compared with 23 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher EDC4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated EDC4 expression acts as an unfavorable survival marker, although some lineages such as COAD and UCEC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where EDC4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	All	0.821	0.945	.005	12	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	9	view →
LUAD	DFS	Median	All	0.680	0.955	.019	7	view →
COAD	DFS	Median	II,III,IV	1.000	0.887	.030	6	view →
CCRCC	DFS	Median	II,III,IV	0.123	0.839	.007	6	view →
UCEC	DFS	Quartile	All	0.965	0.821	.032	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

EDC4–LSCC (OS)

Open the LSCC breakdown →