EDC3

Across TCGA patient cohorts, EDC3 mutation is significantly associated with the RNA expression of many other genes, with 1,338 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible EDC3-associated genes across cancer lineages are SLC2AXP1, MIR3667, and RNA5SP84. Each is linked with EDC3 in more than 1 cancer types. Because this analysis shows association rather than direction, both EDC3-to-partner and partner-to-EDC3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC2AXP1 grouped by EDC3-low versus EDC3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDC3→partner) and Y-score (partner→EDC3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	SLC2AXP1 →	+0.145	+5.788	<.001	.003	3	2
CESC	MIR3667 →	+0.467	+4.196	<.001	.003	3	2
BLCA	RNA5SP84 →	+0.421	+7.307	<.001	<.001	3	2
BRCA	S100A7L2 →	+0.110	+6.442	<.001	.001	3	2
UCEC	RNU1-17P →	+0.168	+2.450	.003	.003	3	2
UCEC	RNU6-918P →	+0.275	+2.513	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,338 associations by consensus.

SLC2AXP1 by EDC3 expression — BLCA

Explore this box plot interactively →