EDA2R

Across TCGA cell cohorts, EDA2R RNA expression is significantly associated with the go_rna of many other GO terms, with 2,276 significant associations in total. BONE shows the largest number of these associations.

The most reproducible EDA2R-associated GO terms across cancer lineages are Regulation of cardiolipin metabolic process, Cellular response to cell-matrix adhesion, and Positive regulation of G0 to G1 transition. Each is linked with EDA2R in more than 8 cancer types. Because this analysis shows association rather than direction, both EDA2R-to-partner and partner-to-EDA2R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cardiolipin metabolic process grouped by EDA2R-low versus EDA2R-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (EDA2R→partner) and Y-score (partner→EDA2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of cardiolipin metabolic process →	-0.177	-1.804	<.001	.001	3	9
KIDNEY	Cellular response to cell-matrix adhesion →	+0.252	+1.890	.003	.002	3	9
KIDNEY	Positive regulation of G0 to G1 transition →	+0.155	+1.510	<.001	<.001	3	8
CNS	Motor neuron apoptotic process →	+0.076	+1.000	.009	.006	3	8
CNS	Response to vitamin B1 →	+0.137	+1.640	<.001	<.001	3	7
SOFT_TISSUE	Negative regulation of iron ion transport →	+0.067	+2.030	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,276 associations by consensus.

Regulation of cardiolipin metabolic process by EDA2R expression — BONE

Explore this box plot interactively →