EDA2R

Across TCGA cell cohorts, EDA2R mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible EDA2R-associated genes across cancer lineages are ZNRF4, RAX, and UTF1. Each is linked with EDA2R in more than 1 cancer types. Because this analysis shows association rather than direction, both EDA2R-to-partner and partner-to-EDA2R results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNRF4 grouped by EDA2R-low versus EDA2R-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (EDA2R→partner) and Y-score (partner→EDA2R) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ZNRF4 →	+0.022	+4.781	<.001	.003	3	1
BREAST	RAX →	+0.011	+4.421	<.001	.004	3	1
BREAST	UTF1 →	+0.060	+4.672	<.001	.002	3	1
BREAST	BHLHA9 →	+0.032	+4.421	<.001	.004	3	1
BREAST	IFNA14 →	+0.027	+4.781	<.001	.003	3	1
BREAST	CD300H →	+0.244	+4.199	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ZNRF4 by EDA2R expression — BREAST

Explore this box plot interactively →