ECM2

Across TCGA patient cohorts, ECM2 mutation is significantly associated with the RNA expression of many other genes, with 646 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECM2-associated genes across cancer lineages are OR51B2, ADAMTS15, and DAPK3. Each is linked with ECM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECM2-to-partner and partner-to-ECM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR51B2 grouped by ECM2-low versus ECM2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECM2→partner) and Y-score (partner→ECM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	OR51B2 →	+0.070	+4.824	<.001	.002	3	2
UCEC	ADAMTS15 →	-1.015	-3.451	.006	.005	3	2
UCEC	DAPK3 →	+0.453	+2.815	.002	.001	3	2
UCEC	LURAP1 →	-0.452	-2.033	.006	.006	3	2
UCEC	C1QA →	+0.858	+2.807	.006	.003	3	2
UCEC	CTU2 →	+0.539	+3.258	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 646 associations by consensus.

OR51B2 by ECM2 expression — COAD

Explore this box plot interactively →