ECI2-DT

Across TCGA pan-cancer cohorts, ECI2-DT RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ECI2-DT data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher ECI2-DT RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ECI2-DT expression acts as an unfavorable survival marker, although some lineages such as KIRC and STAD show a favorable association.

ACC, HNSC, and KIRP are the cancer types where ECI2-DT RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.504	0.811	<.001	67	view →
HNSC	OS	Tertile	IV	0.283	0.712	<.001	43	view →
KIRP	DFS	Median	All	0.469	0.714	.010	41	view →
LGG	OS	Quartile	All	0.284	0.488	<.001	28	view →
SKCM	DFS	Quartile	All	0.674	0.857	.003	14	view →
THCA	OS	Tertile	All	0.874	0.983	.008	14	view →
KIRC	DFS	Tertile	All	0.865	0.707	.006	14	view →
KICH	OS	Quartile	III,IV	0.344	1.000	.002	13	view →
LIHC	OS	Quartile	All	0.651	0.856	.001	12	view →
STAD	OS	Tertile	All	0.506	0.304	.027	10	view →
READ	OS	Tertile	IV	1.000	0.615	.030	7	view →
BLCA	DFS	Median	All	0.388	0.575	.010	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ECI2-DT–ACC (DFS)

Open the ACC breakdown →