ECI2-DT

Across TCGA pan-cancer cohorts, ECI2-DT RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ECI2-DT’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ECI2-DT RNA is repressed in tumor relative to normal tissue. In most cancer types ECI2-DT is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and THCA are the cancer types where ECI2-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ECI2-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−0.491	<.001	11	view →
KICH	Male	All	−0.504	<.001	10	view →
THCA	Male	All	−0.272	<.001	9	view →
LIHC	All	All	+0.135	<.001	7	view →
BRCA	All	II,III,IV	−0.159	<.001	4	view →
LUSC	All	All	−0.102	.001	4	view →
KIRC	All	All	−0.102	.003	4	view →
READ	All	All	−0.310	.013	3	view →
KIRP	Male	All	−0.242	<.001	3	view →
HNSC	All	IV	+0.128	.016	3	view →
BLCA	All	All	−0.087	.037	3	view →
PRAD	All	All	+0.109	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ECI2-DT–COAD

Open the COAD breakdown →