ECHDC1

Across TCGA patient cohorts, ECHDC1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ECHDC1-associated genes across cancer lineages are ER-alpha, MSH2, and BRCA2. Each is linked with ECHDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECHDC1-to-partner and partner-to-ECHDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ER-alpha grouped by ECHDC1-low versus ECHDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECHDC1→partner) and Y-score (partner→ECHDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ER-alpha →	-0.914	-3.000	.033	.036	3	1
UCEC	MSH2 →	-0.423	-3.160	<.001	.019	2	1
UCEC	BRCA2 →	-0.136	-3.314	.041	.010	2	1
UCEC	MEK1 →	+0.754	+3.321	<.001	.010	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ER-alpha by ECHDC1 expression — UCEC

Explore this box plot interactively →