ECE2

Across TCGA cell cohorts, ECE2 RNA expression is significantly associated with the go_rna of many other GO terms, with 570 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible ECE2-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Regulation of myoblast fusion, and Peptidyl-lysine acetylation. Each is linked with ECE2 in more than 4 cancer types. Because this analysis shows association rather than direction, both ECE2-to-partner and partner-to-ECE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by ECE2-low versus ECE2-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ECE2→partner) and Y-score (partner→ECE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.073	+0.970	<.001	<.001	3	5
LUNG_SCLC	Regulation of myoblast fusion →	+0.068	+0.962	<.001	<.001	3	4
BLOOD_Leukemia	Peptidyl-lysine acetylation →	+0.052	+0.009	.002	.007	3	3
BLOOD_Leukemia	Negative regulation of cell cycle G1/S phase transition →	+0.049	+0.007	.005	.002	3	3
LUNG_SCLC	Symbiont-mediated disruption of host cell PML body →	+0.100	+1.433	.002	<.001	3	3
LUNG_SCLC	Cellular response to fibroblast growth factor stimulus →	-0.067	-1.081	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 570 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by ECE2 expression — LUNG_SCLC

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