ECE2

Across TCGA pan-cancer cohorts, ECE2 RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated ECE2 data layer compared with 8 for mutation status.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ECE2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated ECE2 expression acts as an unfavorable survival marker, although some lineages such as UVM and OV show a favorable association.

KIRP, MESO, and BRCA are the cancer types where ECE2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.818	0.941	<.001	130	view →
MESO	OS	Median	All	0.273	0.496	.001	83	view →
BRCA	OS	Tertile	All	0.887	0.955	<.001	74	view →
ACC	DFS	Median	All	0.264	0.665	<.001	71	view →
BLCA	DFS	Quartile	IV	0.135	0.687	<.001	71	view →
KIRC	OS	Quartile	II,III,IV	0.681	0.889	<.001	70	view →
KICH	DFS	Median	II,III,IV	0.683	1.000	.001	68	view →
LUAD	OS	Tertile	All	0.741	0.872	<.001	66	view →
SKCM	OS	Quartile	II,III,IV	0.668	0.837	.001	56	view →
COAD	DFS	Median	IV	0.243	0.692	<.001	43	view →
LIHC	OS	Median	All	0.711	0.837	<.001	43	view →
UCEC	DFS	Tertile	All	0.754	0.881	<.001	42	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

ECE2–KIRP (OS)

Open the KIRP breakdown →