ECE2

Across TCGA cell cohorts, ECE2 mutation is significantly associated with the RNA expression of many other genes, with 1,173 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ECE2-associated genes across cancer lineages are PPIAL4E, DUOXA2, and GPR101. Each is linked with ECE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ECE2-to-partner and partner-to-ECE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPIAL4E grouped by ECE2-low versus ECE2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECE2→partner) and Y-score (partner→ECE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PPIAL4E →	+0.064	+4.669	<.001	<.001	3	1
BLOOD_Leukemia	DUOXA2 →	+0.278	+3.977	<.001	.005	3	1
BLOOD_Leukemia	GPR101 →	+0.102	+3.551	<.001	.009	3	1
BLOOD_Leukemia	MBD3L3 →	+0.029	+3.874	<.001	.005	3	1
BLOOD_Leukemia	CYP4A11 →	+0.029	+3.705	<.001	.007	3	1
BLOOD_Leukemia	C11orf91 →	+0.048	+4.450	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,173 associations by consensus.

PPIAL4E by ECE2 expression — SKIN

Explore this box plot interactively →