ECE1

Across TCGA patient cohorts, ECE1 mutation is significantly associated with the RNA expression of many other genes, with 4,495 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible ECE1-associated genes across cancer lineages are SENP3-EIF4A1, NKAPD1, and OXSM. Each is linked with ECE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ECE1-to-partner and partner-to-ECE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SENP3-EIF4A1 grouped by ECE1-low versus ECE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ECE1→partner) and Y-score (partner→ECE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SENP3-EIF4A1 →	+0.100	+2.515	<.001	<.001	3	3
SKCM	NKAPD1 →	+0.505	+3.195	.008	.009	3	3
UCEC	OXSM →	+0.286	+2.642	.002	<.001	3	3
UCEC	EIF4E →	+0.439	+1.890	<.001	<.001	3	3
UCEC	SAR1B →	+0.556	+3.906	<.001	<.001	3	3
UCEC	UBASH3B →	+0.480	+2.353	.002	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,495 associations by consensus.

SENP3-EIF4A1 by ECE1 expression — UCEC

Explore this box plot interactively →