ECD

Across TCGA pan-cancer cohorts, ECD Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ECD data layer compared with 19 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher ECD Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ECD expression acts as an unfavorable survival marker.

KIRP, LUSC, and COAD are the cancer types where ECD Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	All	0.350	0.711	.001	36	view →
LUSC	OS	Median	All	0.011	0.776	<.001	36	view →
COAD	OS	Median	All	0.122	0.874	<.001	30	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ECD–KIRP (OS)

Open the KIRP breakdown →